Brain glucose metabolism and its relation to amyloid load in middle-aged adults with childhood-onset epilepsy

作者：Joutsa Juho^*; Rinne Juha O; Karrasch Mira; Hermann Bruce; Johansson Jarkko; Anttinen Anu; Eskola Olli; Helin Semi; Shinnar Shlomo; Sillanpaa Matti

来源：Epilepsy Research, 2017, 137: 69-72.

DOI：10.1016/j.eplepsyres.2017.09.006

• Aging
• Alzheimer's
• Epilepsy
• Positron emission tomography
• Imaging

Uncomplicated childhood-onset epilepsy is associated with increased brain amyloid load at late middle age, but its possible association with Alzheimer-type neurodegenerative processes is unclear. After 50-year follow-up, 42 childhood onset epilepsy subjects and 45 matched controls were investigated with [F-18]fluorodeoxyglucose PET. There were no significant differences between the subjects and controls, but higher [18F]fluorodeoxyglucose uptake was associated with a higher local amyloid load (as measured with [C-11]PIB PET) in the prefrontal cortex, parietal cortex, and posterior cingulate/precuneus in subjects but not in controls. These findings parallel reported observations in cognitively normal individuals with increased brain amyloid accumulation who are at risk for future Alzheimer's disease.

• 出版日期2017-11
• 单位MIT