An NF-kappa B-EphrinA5-Dependent Communication between NG(2+) Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates

作者：Gu Jin Mo; Wang David J; Peterson Jennifer M; Shintaku Jonathan; Liyanarachchi Sandya; Coppola Vincenzo; Frakes Ashley E; Kaspar Brian K; Cornelison Dawn D; Guttridge Denis C^*

来源：Developmental Cell, 2016, 36(2): 215-224.

DOI：10.1016/j.devcel.2015.12.018

• NF-κB
• ephrinA5
• skeletal muscle
• myoblast
• migration
• development

Skeletal muscle growth immediately following birth is critical for proper body posture and locomotion. However, compared with embryogenesis and adulthood, the processes regulating the maturation of neonatal muscles is considerably less clear. Studies in the 1960s predicted that neonatal muscle growth results from nuclear accretion of myoblasts preferentially at the tips of myofibers. Remarkably, little information has been added since then to resolve how myoblasts migrate to the ends of fibers. Here, we provide insight into this process by revealing a unique NF-kappa B-dependent communication between NG(2+) interstitial cells and myoblasts. NF-kappa B in NG(2+) cells promotes myoblast migration to the tips of myofibers through cell-cell contact. This occurs through expression of ephrinA5 from NG(2+) cells, which we further deduce is an NF-kappa B target gene. Together, these results suggest that NF-kappa B plays an important role in the development of newborn muscles to ensure proper myoblast migration for fiber growth.

• 出版日期2016-1-25