ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors

作者：Nguyen Liem T; Tretiakova Maria S; Silvis Mark R; Lucas Jared; Klezovitch Olga; Coleman Ilsa; Bolouri Hamid; Kutyavin Vassily I; Morrissey Colm; True Lawrence D; Nelson Peter S; Vasioukhin Valeri^*

来源：Cancer Cell, 2015, 27(6): 797-808.

DOI：10.1016/j.ccell.2015.05.005

The significance of ERG in human prostate cancer is unclear because mouse prostate is resistant to ERG-mediated transformation. We determined that ERG activates the transcriptional program regulated by YAP1 of the Hippo signaling pathway and found that prostate-specific activation of either ERG or YAP1 in mice induces similar transcriptional changes and results in age-related prostate tumors. ERG binds to chromatin regions occupied by TEAD/YAP1 and transactivates Hippo target genes. In addition, in human luminal-type prostate cancer cells, ERG binds to the promoter of YAP1 and is necessary for YAP1 expression. These results provide direct genetic evidence of a causal role for ERG in prostate cancer and reveal a connection between ERG and the Hippo signaling pathway.

• 出版日期2015-6-8