Mannose-Binding Lectin and Susceptibility to Schistosomiasis

作者：Antony Justin S; Ojurongbe Olusola; van Tong Hoang; Abou Ouf Eman; Engleitner Thomas; Akindele Akeem A; Sina Agbaje Olawumi R; Adeyeba Adegboyega O; Kremsner Peter G; Velavan Thirumalaisamy P^*

来源：Journal of Infectious Diseases, 2013, 207(11): 1675-1683.

DOI：10.1093/infdis/jit081

• MBL2
• genotypes
• haplotypes
• serum level
• Schistosomiasis

Background. Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis. %26lt;br%26gt;Methods. We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium-infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis. %26lt;br%26gt;Results. MBL serum levels were significantly higher in controls and were associated with protection (P %26lt; .0001). The -550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes -550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03). %26lt;br%26gt;Conclusions. In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis.

• 出版日期2013-6-1