Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa

作者：Veaute Carolina; Liu De Yi; Furlong Laura I; Biancotti Juan C; Baker H W G; Vazquez Levin Monica H^*

来源：Fertility and Sterility, 2010, 93(7): 2456-2459.

DOI：10.1016/j.fertnstert.2009.08.040

• Human
• fertilization
• spermatozoa
• oocyte
• proacrosin
• acrosin
• antibodies
• acrosome reaction

The anti-acrosin monoclonal antibody AcrC5F10 inhibited proacrosin activation, proacrosin-human zona pellucida glycoprotein A (ZPA) binding, and the zona pellucida (ZP)-induced acrosome reaction of the ZP-bound spermatozoa but had no significant effect on sperm-ZP binding. These results suggest that proacrosin-acrosin may play an important role in the ZP-induced acrosome reaction of spermatozoa after primary binding to the ZP. (Fertil Steril (R) 2010;93:2456-9.

• 出版日期2010-5-1