A plasmonic chip-based bio/chemical hybrid sensing system for the highly sensitive detection of C-reactive protein

作者:Matsuura Ryo; Tawa Keiko; Kitayama Yukiya; Takeuchi Toshifumi*
来源:Chemical communications, 2016, 52(20): 3883-3886.
DOI:10.1039/c5cc07868g

摘要

A synthetic polymer ligand-grafted plasmonic chip was fabricated and demonstrated a highly sensitive detection of C-reactive protein (CRP) by grating-coupled surface plasmon field-enhanced fluorescence. Poly(2-methacryloyloxyethyl-phosphorylcholine) was used as a CRP-specific polymer ligand layer and was grafted onto the plasmonic chip using surface-initiated controlled/living radical polymerization (limit of detection: ca. 10 pM).

  • 出版日期2016