A biocompatibility study on carbon-carbon composite lumbar cage coated with hydroxyapatites

作者：Wang Wen-bo; Dong Jianwen; Cao Ning; Yang Zhenguo; Liu Wenbin; Li Musen; Li Chune

来源：中医正骨, 2014, (4).

• Lumbar vertebrae
• Carbon-carbon composites
• Hydroxyapatites
• Lumbar cage
• Animal experimentation

Objective:To explore the biocompatibility of carbon-carbon composite lumbar cage coated with hydroxyapatites( HA)and the effectiveness of fusion. Methods:The simulated intervertebral fusion surgery were performed in L4/L5 or L5/L6 intervertebral space in 8 adult male hybrid Boer goats. The self-made carbon-carbon composite lumbar cage coated with HA were placed in the intervertebral space and fixed with Kirschner-wire in posterior access. Vital signs and both lower extremities activities of the Boer goats were observed and recorded after the surgery. Radiography were performed in the lumbar vertebraes before the surgery and before the goats were sacrificed respectively. The location of lumbar cage,fusion of lumbar cage and vertebral bodies and the intervertebral space were observed. Four goats were sacrificed at 60th days and 90th days after the surgery respectively,and the two confertus vertebral bodies were fetched,and the histo-logical observation was carried out under naked eye,optical microscope and electron microscope. Results:The X-ray examination showed that the height of intervertebral space where the lumbar cage were placed were 2. 32+/-0. 31,2. 41+/-0. 43 and 2. 40+/-0. 44 mm re-spectively before the surgery,60 days and 90 days after the surgery. Bone formation and fusion were found in the endplate adjacent to lumbar cage 60 days and 90 days after the surgery. The histological observation showed that the trabeculae of bone could be found in the bone graft area of lumbar cage and around the lumbar cage 60 days after the surgery. The trabecular bone arranged regularly at the 90 days after the surgery,a layer of fibrous connective tissue were found around the cage and it grow thin gradually,and the bone tissue and fibrous tissue grew into the cage. Conclusion:The carbon-carbon composite lumbar cage coated with HA has good biocompatibility and stability,and it is helpful to bone graft fusion,so it can be used as the internal fixation apparatus for intervertebral fusion.

• 出版日期2014
• 单位山东中医药大学