Distribution and Dynamics of Transcription-Associated Proteins during Parvovirus Infection

作者：Ihalainen Teemu O; Willman Sami F; Niskanen Einari A; Paloheimo Outi; Smolander Hanna; Laurila Juha P; Kaikkonen Minna U; Vihinen Ranta Maija^*

来源：Journal of Virology, 2012, 86(24): 13779-13784.

DOI：10.1128/JVI.01625-12

Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.

• 出版日期2012-12