Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing

作者：Lim Efrem S; Reyes Alejandro; Antonio Martin; Saha Debasish; Ikumapayi Usman N; Adeyemi Mitchell; Stine O Colin; Skelton Rebecca; Brennan Daniel C; Mkakosya Rajhab S; Manary Mark J; Gordon Jeffrey I; Wang David^*

来源：Virology, 2013, 436(2): 295-303.

DOI：10.1016/j.virol.2012.12.005

• Polyomavirus
• Virus discovery
• Tumor antigen
• Alternative splicing
• Recombination

The family Polyomaviridae is comprised of circular double-stranded DNA viruses, several of which are associated with diseases, including cancer, in immunocompromised patients. Here we describe a novel polyomavirus recovered from the fecal microbiota of a child in Malawi, provisionally named STL polyomavirus (STLPyV). We detected STLPyV in clinical stool specimens from USA and The Gambia at up to 1% frequency. Complete genome comparisons of two STLPyV strains demonstrated 5.2% nucleotide divergence. Alternative splicing of the STLPyV early region yielded a unique form of T antigen, which we named 229T, in addition to the expected large and small T antigens. STLPyV has a mosaic genome and shares an ancestral recombinant origin with MWPyV. The discovery of STLPyV highlights a novel alternative splicing strategy and advances our understanding of the complex evolutionary history of polyomaviruses.

• 出版日期2013-2-20