Adaptive immunity in inflammatory bowel disease: state of the art

作者：Kaser Arthur^*; Blumberg Richard S

来源：Current Opinion in Gastroenterology, 2008, 24(4): 455-461.

DOI：10.1097/MOG.0b013e328304d60d

• adaptive immunity
• Crohn's disease
• inflammatory bowel disease
• T helper type 17
• T regulatory cells
• ulcerative colitis

Purpose of review
Adaptive immune mechanisms are inherently involved in the pathogenesis of inflammatory bowel disease. This review summarizes the main discoveries made in 2007 within this field.
Recent findings
CD4(+) T cells secreting interleukin-17 (T helper type 17) cells have emerged as a key effector population driving colitis in animal models previously associated with exaggerated T helper type 1 responses. With regard to T-regulatory cells, a novel suppressive cytokine (interleukin-35) and induction of apoptosis as a means to exert suppression have been identified. The importance of specific chemokine receptors and integrins in effector and T-regulatory cell function in colitis has been recognized.
Summary
An improved understanding of adaptive immune mechanisms, on which manifold genetic and environmental traits might converge, and which ultimately mediate intestinal inflammation in inflammatory bowel disease, holds promise for novel effective therapeutic intervention.

• 出版日期2008-7