Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma

作者：Rennert Robert C; Achrol Achal S; Januszyk Michael; Kahn Suzana A; Liu Tiffany T; Liu Yi; Sahoo Debashis; Rodrigues Melanie; Maan Zeshaan N; Wong Victor W; Cheshier Samuel H; Chang Steven D; Steinberg Gary K; Harsh Griffith R; Gurtner Geoffrey C

来源：Stem Cells, 2016, 34(6): 1702-1707.

DOI：10.1002/stem.2359

• Glioblastoma
• Brain tumor initiating cells
• Microfluidics
• Molecular heterogeneity

Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies.

• 出版日期2016-6