A bioactive cycloartane triterpene from Garcinia hombroniana

作者：Jamila Nargis^*; Khan Naeem; Khan Imran; Khan Amir Atlas; Khan Sadiq Noor

来源：Natural Product Research, 2016, 30(12): 1388-1397.

DOI：10.1080/14786419.2015.1060594

• Garcinia hombroniana
• (22Z,24E)-3 beta-hydroxycycloart-14,22,24-trien-26-oic acid
• acetylcholinesterase
• butyrylcholinesterase

The dichloromethane bark extract of Garcinia hombroniana yielded one new cycloartane triterpene; (22Z,24E)-3 beta-hydroxycycloart-14,22,24-trien-26-oic acid (1) together with five known compounds: garcihombronane G (2), garcihombronane J (3), 3 beta acetoxy-9 alpha-hydroxy-17,14-friedolanostan-14,24-dien-26-oic acid (4), (22Z, 24E)-3 beta, 9 alpha-dihydroxy-17,14-friedolanostan-14,22,24-trien-26-oic acid (5) and 3 beta, 23 alpha-dihydroxy-17,14-friedolanostan-8,14,24-trien-26-oic acid (6). Their structures were established by the spectral techniques of NMR and ESI-MS. These compounds together with some previously isolated compounds; garcihombronane B (7), garcihombronane D (8) 2,3',4,5'-tetrahydroxy-6-methoxybenzophenone (9), volkensiflavone (10), 4 ''-O-methyll-volkensiflavone (11), volkensiflavone-7-O-glucopyranoside (12), volkensiflavone-7-O-rhamnopyranoside (13), Morelloflavone (14), 3 ''-O-methyl-morelloflavone (15) and morelloflavone-7-O-glucopyranoside (16) were evaluated for cholinesterase enzymes inhibitory activities using acetylcholinesterase and butyrylcholinesterase. In these activities, compounds 1-9 showed good dual inhibition on both the enzymes while compounds 10-16 did not reasonably contribute to both the cholinesterases inhibitory effects.

• 出版日期2016