科研之友
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摘要
Arabinogalactan isolated from grass protects from allergic disease The prevalence of allergic disease in industrialized countries is increasing. Allergies develop on the background of a genetic predisposition modulated by environmental factors. Although circumstances leading to aggravation or alleviation of allergic disease are not completely understood, epidemiological studies revealed an allergy protective effect of farm living and frequent contacts to cowsheds in early childhood. Cowshed dust contains a broad range of immune modulatory molecules. Microbial as well as molecules from plant origin are detectable in extracts, although microbial molecules only at low concentration. Interestingly, in a mouse model of asthma extracts from cowshed dust collected on traditional farms protect against the allergic disease. Now we were able to show that cowshed dust extract contains plant arabinogalactan. Similar to the whole extract these polysaccharides protect from allergic asthma in the murine model system. One mechanism responsible for protection is the modulation of dendritic cell function by arabinogalactan. After stimulation of cells with this polysaccharide, cells produce interleukin-10 leading to down-regulation of sensitization capacity of dendritic cells. Since we have evidence that arabinogalactan is also modulating the function of human dendritic cells we suggest that these polysaccharides may serve as a prophylactic treatment for allergic disease in human.
- 出版日期2011-9
