Activation of T cell death-associated gene 8 attenuates inflammation by negatively regulating the function of inflammatory cells

作者：Onozawa Yoshiko; Komai Tomoaki; Oda Tomiichiro^*

来源：European Journal of Pharmacology, 2011, 654(3): 315-319.

DOI：10.1016/j.ejphar.2011.01.005

• T cell death-associated gene 8
• G-protein-coupled receptor
• Knockout mouse
• Anti-type II collagen antibody-induced arthritis
• Delayed-type hypersensitivity
• Collagen-induced arthritis

T cell death-associated gene 8 (TDAG8) is a G-protein-coupled receptor identified by differential mRNA display during thymocyte apoptosis induced by T cell receptor engagement. To examine the physiological role of an orphan G-protein-coupled receptor TDAG8 in inflammation, we studied various immune-mediated inflammatory disease models using TDAG8-deficient mice. We found that TDAG8-deficient mice showed significant exacerbation of anti-type II collagen antibody-induced arthritis and delayed-type hypersensitivity, and showed a slight exacerbation of collagen-induced arthritis. These results suggest that TDAG8 acts as a negative regulator of inflammation.

• 出版日期2011-3-11