科研之友
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摘要
The immune-modulating effect following intradermal injection of various-sized amorphous silica particles was analyzed in terms of induction of ovalbumin-specific CD8(+) T cells in vivo. IFN-gamma ELISPOT assays revealed that only nanosilica particles with a diameter of less than 100 nm significantly enhanced CD8(+) T cell responses against ovalbumin. These results indicate that the size of nano-materials is a critical determinant in terms of their safe use.
- 出版日期2011-9
