Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis

作者：Nabeshima Yo ichi^*

来源：Proceedings of the Japan Academy Series B-Physical and Biological Sciences, 2009, 85(3): 125-141.

DOI：10.2183/pjab/85.125

• mineral homeostasis
• alpha-Klotho
• FGF23
• PTH
• Vitamin D
• Na
• K -ATPase

alpha-Klotho was first identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. alpha-Klotho has been shown to participate in the regulation of parathyroid hormone secretion and trans-epithelial transport of Ca2 in the choroid plexus and kidney. alpha-Klotho, acting as a cofactor for FGF23, is also a major regulator of vitamin D biosynthesis and phosphate reabsorption in the kidney. These suggest that a-Klotho is a key player that integrates a multi-step regulatory system of calcium and phosphate homeostasis. Collectively, the molecular function of a-Klotho reveals a new paradigm that may change current concepts in mineral homeostasis and give rise to new insights in this field.

• 出版日期2009-3