Disease Modification Promising Targets and Impediments to Success

作者：Matthews Gloria L^*

来源：Rheumatic Disease Clinics of North America, 2013, 39(1): 177-+.

DOI：10.1016/j.rdc.2012.10.006

• Osteoarthritis
• Disease modification
• Clinical trial
• Joint

Osteoarthritis (OA) is a significant and growing concern to a large segment of the population. Effective treatments for slowing or stopping the progression of the disease are not available despite a great deal of investment-backed effort on the part of academia, government, and the pharmaceutical industry. Target selection has been problematic. Progress may also have been hindered to some extent by the prevalent cartilage-centric view of OA. Significant clinical development challenges remain for novel therapeutics in this area. This review elaborates on the challenges of disease-modifying OA drug development and points out specific therapeutic intervention strategies recently tried or currently being pursued.

• 出版日期2013-2