科研之友
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摘要
Cancer is one of the major fatal diseases. Chemotherapy is a typical treatment method that uses a combination of drugs to either destroy cancer cells or slow down the growth of cancer cells. However, most of the cytotoxic chemotherapeutic drugs are water insoluble resulting in formulation difficulty. One promising strategy is to use cyclodextrins (CDs) which have been widely employed to enhance the solubility, bioavailability, stability and safety of drug molecules by forming non covalent inclusion complexes. The objective of this review is to explain the use of CDs in the different approaches for cancer treatment. Of specific interest is that CDs are shown to have anticancer activity both in vitro and in vivo. The use of CDs as anticancer agent and the possible mechanism to inhibit cancer cell growth are discussed. CDs/anti-neoplastic-drug complexes with improved solubility, increased stability and enhanced anti-cancer activity are described and possible future applications are discussed. Use and their advantages of CDs in the different drug delivery systems like liposomes, conjugates, nanoparticles and siRNA carriers for cancer treatment are detailed in this review. These CDs modified delivery system for anticancer drugs are shown to provide improved encapsulation, prolonged release, increased therapeutic efficacy and reduced toxicity. Furthermore, there is a prerequisite to exploit the utility of CDs and CDs-based carriers using in vivo tumor models for pharmacokinetics, pharmacodynamics and toxicity studies to validate their safety and efficacy. In future, we believe that CDs and CDs-based delivery system for anticancer drugs have great potential to serve as an alternative for cancer treatment.
- 出版日期2017-12
- 单位成都理工大学
