Association between VEGF polymorphisms (936c/t,-460t/c and-634g/c) with haplotypes and coronary heart disease susceptibility

作者：Han, Xia; Liu, Lili; Niu, Jiamin; Yang, Jun; Zhang, Zengtang^*; Zhang, Zhiqiang

来源：International Journal of Clinical and Experimental Pathology, 2015, 8(1): 922-927.

• Coronary heart disease
• vascular endothelial growth factor
• polymorphism
• haplotype

Aim: Our aim was to investigate the association between single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor (VEGF) and coronary heart disease (CHD) susceptibility in Chinese Han population. Methods: 144 CHD patients and 150 healthy individuals were enrolled in the study. Three SNPs (936C/T, -460T/C and -634G/C) of VEGF were chose and then were genotyped with Sequenom time-of-flight mass spectrometry (TOFMS). Odds ratio (OR) with 95% confidence interval (CI) were used to evaluate the association of genotypes and haplotypes and CHD susceptibility. Results: The frequencies of -460T/C CC genotype (13.6%) was found higher in the case group than that of control group (6.7%), which indicated that CC genotype was a risk factor for CHD (OR= 2.50, 95% CI= 1.10-5.68). Correspondently, the C allele appeared to increase the risk of CHD (OR= 1.54, 95% CI= 1.07-2.22). For -634G/C polymorphism, the risk of the CC genotype carrier for CHD increased 2.24 fold compared to the wild genotype. Moreover, -634G/CC allele was significantly associated with CHD susceptibility (OR= 1.65, 95% CI= 1.15-2.36). In addition, + 936C/T CT genotype and C allele appeared to be a genetic-susceptibility factors for CHD (OR= 2.43, 95% CI= 1.44-4.10; OR= 1.95, 95% CI= 1.26-3.02). The haplotype analysis showed that T-C-T, C-C-C and C-G-C haplotypes all could increase the risk for CHD (OR: 2.43, 2.77 and 2.33). Conclusion: we concluded VEGF polymorphisms were associated with CHD susceptibility. Moreover, the haplotypes of T-C-T, C-C-C and C-G-C all could increase the risk for CHD.

• 出版日期2015
• 单位青岛大学; 烟台毓璜顶医院