A novel tool for predicting extracapsular extension during graded partial nerve sparing in radical prostatectomy

作者：Patel Vipul R.; Sandri Marco; Grasso Angelica A. C.; De Lorenzis Elisa; Palmisano Franco; Albo Giancarlo; Coelho Rafael F.; Mottrie Alexander; Harvey Tadzia; Kameh Darian; Palayapalayam Hariharan; Wiklund Peter; Bosari Silvano; Puliatti Stefano; Zuccolotto Paola; Bianchi Giampaolo; Rocco Bernardo^*

来源：BJU International, 2018, 121(3): 373-382.

DOI：10.1111/bju.14026

• extracapsular extension
• prostate
• robotic prostatectomy
• staging
• nomogram
• prostate cancer

Objectives
To create a statistical tool for the estimation of extracapsular extension (ECE) level of prostate cancer and determine the nerve-sparing (NS) approach that can be safely performed during radical prostatectomy (RP).
Patients and Methods A total of 11 794 lobes, from 6 360 patients who underwent robot-assisted RP between 2008 and 2016 were evaluated. Clinicopathological features were included in a statistical algorithm for the prediction of the maximum ECE width. Five multivariable logistic models were estimated for: presence of ECE and ECE width of > 1, > 2, > 3, and > 4 mm. Afive-zone decision rule based on a lower and upper threshold is proposed. Using a graphical interface, surgeons can view patient's pre-treatment characteristics and a curve showing the estimated probabilities for ECE amount together with the areas identified by the decision rule.
Results Of the 6 360 patients, 1 803 (28.4%) were affected by non-organ-confined disease. ECE was present in 1 351 lobes (11.4%) and extended beyond the capsule for > 1, > 2, > 3, and > 4 mm in 498 (4.2%), 261 (2.2%), 148 (1.3%), 99 (0.8%) cases, respectively. ECE width was up to 15 mm (interquartile range 1.00-2.00). The five logistic models showed good predictive performance, the area under the receiver operating characteristic curve was: 0.81 for ECE, and 0.84, 0.85, 0.88, and 0.90 for ECE width of > 1, > 2, > 3, and > 4 mm, respectively.
Conclusion This novel tool predicts with good accuracy the presence and amount of ECE. Furthermore, the graphical interface available at www.prece.it can support surgeons in patient counselling and preoperative planning.

• 出版日期2018-3