Ability of Brucella abortus rough vaccine strains to elicit DC and innate immunity in lung using a murine respiratory model

作者：Surendran Naveen; Zimmerman Kurt; Seleem Mohamed N; Sriranganathan Nammalwar; Boyle Stephen M; Hiltbold Elizabeth M; Lawler Heather; Heid Bettina; Witonsky Sharon G^*

来源：Vaccine, 2010, 28(43): 7009-7015.

DOI：10.1016/j.vaccine.2010.08.039

• Rough vaccine strains RB51 and RB51SOD
• Pulmonary innate immunity
• Intranasal vaccination

Brucella abortus strains RB51 and RB51SOD are live attenuated vaccine strains which protect mice against virulent B. abortus strain 2308 intraperitoneal challenge. By comparison, limited information is available on how Brucella vaccines stimulate pulmonary immunity against respiratory infection, another route of exposure in humans. Therefore, in this study, we assessed the ability of intranasally delivered vaccine strains RB51 and RB51SOD to induce innate immunity. Based on parameters assessed, rough strain RB51 induces a better innate immune response in lung versus strain RB51SOD. Additional studies to further delineate strain RB51's ability to stimulate DC and adaptive immunity are warranted. Published by Elsevier Ltd.

• 出版日期2010-10-8
• 单位美国弗吉尼亚理工大学(Virginia Tech)