A Meta-Analysis of Mesenchymal Stem Cells in Animal Models of Parkinson's Disease

作者：Riecke Jenny; Johns Katherine M; Cai Chunyan; Vahidy Farhaan Shaheer; Parsha Kaushik; Furr Stimming Erin; Schiess Mya; Savitz Sean I^*

来源：Stem Cells and Development, 2015, 24(18): 2082-2090.

DOI：10.1089/scd.2015.0127

Multiple studies have been performed to evaluate the effects of mesenchymal stem cells (MSCs) in animal models of Parkinson's disease (PD). We performed a meta-analysis to estimate the treatment effect of unmodified MSCs on behavioral outcomes in preclinical studies of PD. We performed a systematic literature search to identify studies that used behavioral testing to evaluate the treatment effect of unmodified MSCs in PD models. Meta-analysis was used to determine pooled effect size for rotational behavior and limb function, and meta-regression was performed to explore sources of heterogeneity. Twenty-five studies, including three delivery routes, a wide range of doses, and multiple PD models, were examined. Significant improvement was seen in the pooled standardized mean difference (SMD) for both rotational behavior [SMD: 1.24, 95% confidence interval (95% CI): 0.84, 1.64] and limb SMD: 0.84, 95% CI: 0.01, 1.66). Using meta-regression, intravenous administration and higher dose had a larger effect on limb function. Treatment with MSCs improves behavioral outcomes in PD models. Our analyses suggest that MSCs could be considered for early-stage clinical trials in the treatment of PD.

• 出版日期2015-9-15