A Prospective Study of Serotonin Transporter Gene Promoter (5-HTT Gene Linked Polymorphic Region) and Intron 2 (Variable Number of Tandem Repeats) Polymorphisms as Predictors of Trauma Response to Mild Physical Injury

作者：Sayin Aslihan^*; Kucukyildirim Sibel; Akar Taner; Bakkaloglu Zekiye; Demircan Ahmet; Kurtoglu Gulhan; Demirel Birol; Candansayar Selcuk; Mergen Hatice

来源：DNA and Cell Biology, 2010, 29(2): 71-77.

DOI：10.1089/dna.2009.0936

The aim of this study was to examine the effect of both promoter and intron polymorphisms of the serotonin transporter (5HTT) gene on posttraumatic stress disorder ( PTSD) development. For this purpose, two polymorphisms of the 5-HTT gene, which are found in the promoter (5-HTT gene-linked polymorphic region) and second intron (variable number of tandem repeats) of the gene, were analyzed in 100 patients who were admitted to the Emergency Department after a mild physical trauma. None of the 5-HTT polymorphisms studied have an effect on PTSD development after a mild physical injury, but having L allele for 5-HTT gene-linked polymorphic region may cause milder hyperarousal symptoms in those patients who have developed PTSD.

• 出版日期2010-2