MRI quantitative T2*mapping on thrombus to predict recanalization after endovascular treatment for acute anterior ischemic stroke

作者：Bourcier R; Brecheteau N^*; Costalat V; Daumas Duport B; Guyornarch De****lle B; Desal H; Naggara O; Serfaty J M

来源：Journal of Neuroradiology, 2017, 44(4): 241-246.

DOI：10.1016/j.neurad.2017.03.006

• Quantitative
• T2*
• Mapping
• Thrombus
• Stroke

Background. - In anterior acute ischemic stroke (AAIS) treated with endovascular treatment (EVT), the susceptibility vessel sign (SVS+ or SVS-) is related to recanalization results (TICI 2b/3) and clinical outcome. However, a binary qualitative assessment of thrombus using SVS does not reflect its complex composition. Our aim was to assess whether a quantitative MRI marker, Thrombus-T2* relaxation time, may be assessable in clinical routine and may to predict early successful recanalization after EVT, defined as a TICI 2b/3 recanalization obtained in 2 attempts or less.
Material and methods. -Thrombus-T2* relaxation time was prospectively obtained from consecutive AAIS patients treated by EVT (concomitant aspiration and stent retriever). Quantitative values were compared between early recanalization and late or unsuccessful recanalization. Results. - Thirty patients with AAIS were included and Thrombus-T2* relaxation time was obtained in all patients. Earlier TICI 2b/3 recanalization were obtained in 22 patients (73%) and was significantly associated with SVS+ (1/8 vs. 16/22, P=0.01) and a shorter Thombus-T2* relaxation time (mean SD, range: 257, 18-50 ms vs. 45 9, 35-60 ms, P < 0.001).
Conclusion. -A new quantitative MRI biomarker, the Thrombus-T2* relaxation time is assessable in clinical routine. In a preliminary study of 30 patients, a shorter Thombus-T2* relaxation time is related to earlier recanalization after EVT using combination of stent retriever and aspiration.

• 出版日期2017-7