An Expedient Asymmetric Synthesis of N-Protected (S,S)-2-Aminomethyl-1-cyclopropanecarboxylic Acid

作者：Aitken David J^*; Bull Steven D; Davies Iwan R; Drouin Ludovic; Ollivier Jean; Peed Jennifer

来源：Synlett, 2010, 2010(18): 2729-2732.

DOI：10.1055/s-0030-1258814

• aldol reaction
• amino acids
• asymmetric synthesis
• carbocycle
• chiral auxiliary
• enantioselectivity

An enantioselective synthesis of a N-Boc-protected trans-cyclopropane gamma-amino acid is reported. The key chiral aldehyde intermediate is prepared in enantiomerically pure form using a three-step aldol-cyclopropanation-retro-aldol protocol.

• 出版日期2010-11