Anti-enterovirus 71 activity screening of Taiwanese folk medicinal plants and immune modulation of Ampelopsis brevipedunculata (Maxim.) Trautv against the virus

作者：Hsu Hsing Wen; Wang Jen Hsien; Liu Chaio Li; Chen Chin Shuh; Wang Yuan Chuen^*

来源：African Journal of Microbiology Research, 2011, 5(17): 2500-2511.

• Antienterovirus 71 activity
• Ampelopsis brevipedunculata (Maxim.) Trautv
• immune modulation
• medicinal plant

Enterovirus 71 (EV71) infection caused host immune responses and resulted in severe pathogenicity. In this study, a preliminary anti-EV71 activity of 58 Taiwanese folk medicinal plants and further investigations of the anti-EV71 activity and immunomodulatory effect of Ampelopsis brevipedunculata (Maxim.) Trautv (ABT) were performed. Of the 58 plant extracts, 37 extracts exhibited anti-EV71 activity and strong activity was demonstrated by six extracts with average 50% inhibitory concentrations (IC(50)) below 80 mu g/ml. The ABT (one of the most effective plants) acetone extract exhibited relatively high anti-EV71 activity with 26.11 mu g/ml of average IC(50), 3.6% of that of the positive control (ribavirin, 734.52 mu g/ml). The anti-EV71 modes of the ABT extract included viral infection prevention, viral inactivation and anti-viral replication. Acidic pH treatments slightly decreased anti-EV71 activity of the extract. The ABT extract significantly increased the interlukin-6 (IL-6) and IL-1 beta and decreased the IL-8 levels in the EV71-infected cells. In summary, a high rate of the screened plants exhibited anti-EV71 activity and the greatest activity was demonstrated by ABT. High amounts of IL-6 induction in the infected-cells had high correlation with the anti-viral replication of the ABT extract.

• 出版日期2011-9-9
• 单位中国医科大学