A New Quadruple Hydrogen-Bonding Module Based on Five-Membered Heterocyclic Urea Structure

作者：Hisamatsu Yosuke^*; Shirai Naohiro; Ikeda Shin ichi; Odashima Kazunori

来源：Organic Letters, 2010, 12(8): 1776-1779.

DOI：10.1021/ol100385b

N,N'-Di-4-triazolylurea (DTU) has developed as a new ADDA module and DTU forms a stable ADDA center dot DAAD heterocomplex with 2,7-diamido1,8-naphthyridine (DAN) (K(s) = 2.6 x 10(5) M(-1) in CHCl(3)). The K, value of the complex between DTU and DAN is 100-fold greater than that of the complex between N,N'-di-2-pyridylurea and DAN due to replacement of a pyridine ring with a 1,2,3-triazole ring.

• 出版日期2010-4-16