Abnormal pituitary-gonadal axis may be responsible for rat decreased testicular function under simulated microgravity

作者：Zhou Yi; Tan Xin^*; Zhu Bao an; Qi Meng di; Ding Su ling

来源：Acta Astronautica, 2008, 63(7-10): 974-979.

DOI：10.1016/j.actaastro.2008.05.001

• simulated microgravity
• testosterone
• LH
• FSH
• estradiol
• pituitary-gonadal axis

Space flight and simulated microgravity lead to Suppression of mammalian spermatogenesis and decreased plasma testosterone level. In order to explain the mechanism behind the depression. we used rat tail-suspended model to simulate weightless conditions. To prevent cryptorchidism caused by tail-suspension. some experimental animals received inguinal canal ligation. The results showed that mass of testis decreased significantly and seminiferous tubules became atrophied in rats after tail-suspension. The levels of plasma testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in tail-suspended rats with or without inguinal canal ligation decreased significantly compared with controls, and an increased level of plasma estradiol (E(2)) was revealed in tail-suspended rats. The results indicate that besides the direct influence of fluid shift upon testis under short-term simulated microgravity. the pituitary function is also disturbed as a result of either immobilization stress or weight loss during tail-suspension treatment. which is responsible to some extent for the decreased testosterone secretion level and the atrophia of testis. The conversion of testosterone into E(2) under Simulated microgravity is another possible cause for the decline of plasma testosterone.

• 出版日期2008-11
• 单位北京理工大学