Analysis of neutrophil gelatinase-associated lipocalin in the critical patient

作者：Marti Macia C^*; Tomasa T M; Sancho A; Galan A; Fernandez Llamazares J; Macias V; Roca J; Gonzalez Celador R; Amestoy E; Klamburg J

来源：Medicina Intensiva, 2014, 38(3): 146-153.

DOI：10.1016/j.medin.2013.03.014

• Neutrophil gelatinase-associated lipocalin Protein
• NGAL
• Acute renal failure
• Critical illness

Objective: To determine if NGAL value exceeding 150ng/mL is a good diagnostic test for acute renal failure in critically ill patients. %26lt;br%26gt;Design: Prospective, observational cohort. %26lt;br%26gt;Setting: Intensive Care Unit and Cardiac Surgery Intensive Care Service at Hospital Germans Trias I Pujol. %26lt;br%26gt;Participants: Patients admitted to the Intensive Care department the Designated days in the studio. %26lt;br%26gt;Interventions: Analysis of serum creatinine blood given from 7 days prior to the start of the study, and daily during 4 weeks and by determination of NGAL urine test in frozen sample, analyzer ARCHITECT (Abbott Diagnostics) determined by immunoassay the day baseline and 2 times a week for 4 weeks, analysis of the stay and mortality. %26lt;br%26gt;Results: A total of 529 NGAL samples were obtained from 46 patients. 37% of patients had a value of NGAL %26gt;150ng/mL. The Sensivity of the test to diagnose acute renal failure was 69%, Specifity was 75,7%. However, the Positive Predictive Test Value was 53%, which means that 47% of patients with high NGAL did not develop AKI. A NGAL %26gt;150mg/dL was associated with a significantly higher SOFA and a longer stay in the ICU. The mortality of patients with elevated NGAL was 58.8%. %26lt;br%26gt;Conclusions: A NGAL %26gt;150ng/mL does not seem to be an excellent test for AKI in critically ill patients but is associated with a worse prognosis.

• 出版日期2014-4