Diamino acid derivatives of PpIX as potential photosensitizers for photodynamic therapy of squamous cell carcinoma and prostate cancer: In vitro studies

作者：Kwitniewski Mateusz^*; Juzeniene Asta; Ma Li Wei; Glosnicka Renata; Graczyk Alfreda; Moan Johan

来源：Journal of Photochemistry and Photobiology B: Biology , 2009, 94(3): 214-222.

DOI：10.1016/j.jphotobiol.2008.11.005

• Photodynamic therapy
• Porphyrins
• Photosensitizers
• Squamous cell carcinoma
• Prostate cancer

Photodynamic therapy (PDT) is an alternative treatment modality involving light activated drugs, called photosensitizers (PSs), to treat cancer and non-cancerous conditions. The search for new compounds which might become effective PSs is the major direction for PDT development. In the present work we have studied the dark toxicity, intracellular localization and photodynamic properties of four potential, water soluble, second generation PSs - PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), PP(Phe)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX. Human prostate cancer (DU-145) and squamous carcinoma (A431) cells were used as experimental model.
Among investigated compounds PP(Ser)(2)Arg(2) exhibited the lowest dark toxicity and the highest PDT effectiveness towards both cell lines. Fluorescence microscopy revealed the time-dependent changes in intracellular localization of the PS which were related to the phototoxicity. The results show that PP(Ser)(2)Arg(2) may be a potential PS for PDT.

• 出版日期2009-3-3