A plasmonic nanosensor with inverse sensitivity for circulating cell-free DNA quantification

作者:Pallares Roger M; Kong Say Li; Ru Tan Hui; Thanh Nguyen T K; Lu Yi; Su Xiaodi*
来源:Chemical communications, 2015, 51(77): 14524-14527.
DOI:10.1039/c5cc05331e

摘要

A plasmonic nanosensor (using gold nanorods) with inverse sensitivity is presented for circulating cell-free DNA quantification. The inverse sensitivity (i.e. the lower the analyte concentration, the higher the response intensity) is achieved by the unusual DNA concentration-dependent gold nanorod aggregation. This assay method can adjust the dynamic range by controlling the concentration of nanoparticles in solution.

  • 出版日期2015