The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications

作者：De Leo V^*; Musacchio M C; Piomboni P; Di Sabatino A; Morgante G

来源：European Journal of Obstetrics & Gynecology and Reproductive Biology, 2011, 157(1): 63-66.

DOI：10.1016/j.ejogrb.2011.03.024

• PCOS
• Pregnancy
• Metformin
• Complications

Objectives: To prospectively evaluate the safety of metformin administration during pregnancy in a group of PCOS patients by assessing its effect on the prevalence of gestational complications and neonatal outcome.
Study design: Our prospective, single centre study included 98 pregnant women with PCOS treated with metformin throughout pregnancy and 110 normal pregnant controls. All PCOS patients were hyperinsulinemic and received metformin (1700-3000 mg/day) before conception and until 37 weeks' gestation.
Results: Metformin treatment in the pregnant PCOS patients resulted in significant decrease in miscarriage rate (9.1% vs 20%; p < 0.05), gestational diabetes (0 vs 13%; p < 0.005), and gestational hypertension (0 vs 11%; p < 0.005) and a non-significant decrease in pre-eclampsia (0 vs 3%; p = .24), compared to the control group. Mean neonatal Apgar score, weight and length were comparable between the two groups.
Conclusions: Continuing metformin therapy throughout pregnancy resulted in significant reduction in pregnancy complications with concomitant improved neonatal outcome, with no serious deleterious side effects.

• 出版日期2011-7