Blood pressure lowering efficacy of clonidine for primary hypertension

作者：Musini Vijaya M^*; Pasha Pouneh; Wright James M

来源：Cochrane Database of Systematic Reviews, 2015, (3): CD008284.

DOI：10.1002/14651858.CD008284.pub2

This is the protocol for a review and there is no abstract. The objectives are as follows:
Primary objective
To assess the dose-related effect of clonidine as compared to placebo on systolic and diastolic blood pressure in patients with primary hypertension.
To assess the dose-related effect of clonidine as compared to placebo on systolic and diastolic blood pressure in postmenopausal women with hot flashes without hypertension
To assess the dose-related effect of clonidine as compared to placebo on systolic and diastolic blood pressure in patients treated for opoid withdrawal without hypertension
To assess the dose-related effect of clonidine as compared to placebo on systolic and diastolic blood pressure in patients treated for alcohol addiction without hypertension
Secondary objectives
To assess the dose-related effect of clonidine on heart rate.
To assess the effect of clonidine on pulse pressure.
To assess the effect of clonidine on blood pressure variability.
To assess the effect of clonidine on withdrawals due to adverse effects.

• 出版日期2015