Molecular characteristics of multifocal invasive mucinous adenocarcinoma of the lung: Report of a rare case

作者：Tian, Yan; Zheng, Wenqi; Ge, Huijing; Wang, Yufei; Zha, Nashunbayaer; Huang, Shaojun; Guo, Zhanlin^*

来源：Thoracic Cancer, 2017, 8(6): 710-713.

DOI：10.1111/1759-7714.12495

• Invasive mucinous adenocarcinoma
• lung cancer
• targeted therapy
• thoracoscopic

Invasive mucinous adenocarcinoma (IMA) is an uncommon entity in the lung, with a poor prognosis. Multifocal IMA of the lung is even more unusual, and there is little experience with effective treatments. Herein, we present a case of multifocal IMA diagnosed in a 36year-old man by video-assisted thoracoscopic surgery. A right middle lobe and a nodule in the right upper lobe were resected, as were mediastinal lymph nodes, leaving behind an autonomous right lower lobe nodule. To explore the feasibility of molecular treatment, next-generation sequencing of genetic mutations was performed after four cycles of chemotherapy (pemetrexed+cisplatin). Ultimately, a KIAA1468-RET fusion gene was detected at a disproportionate level (67.3%), indicating that targeted therapy may be efficacious in treating this disease.

• 出版日期2017-11
• 单位内蒙古医科大学