Pathophysiology of systemic lupus erythematosus

作者:Blanco Patrick; Pellegrin Jean Luc; Moreau Jean Francois; Viallard Jean Francois
来源:Presse Medicale, 2007, 36(5): 825-834.
DOI:10.1016/j.lpm.2006.11.017

摘要

Innate immunity is directly implicated in the pathophysiology of lupus through the dendritic cell system and the activation by immune complexes of some toll-like receptors (TLR).
Interferon-alpha ploys a key role in the pathophysiology of lupus and represents a promising target for immune therapy
Dendritic cells ore activated and able to capture large quantities of nuclear antigen-containing bodies to stimulate specific adoptive immune response.