An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

作者：Martins Ana Caroline V^*; de Lima Neto Pedro; Barroso Neto Ito L; Cavada Benildo S; Freire Valder N; Caetano Ewerton W S

来源：RSC Advances, 2013, 3(35): 14988-14992.

DOI：10.1039/c3ra42149j

We report quantum biochemistry calculations focusing on the binding pocket of the glutamate receptor co-crystallized with agonists (full and partial) and a antagonist. The calculated electronic binding energy follows the order AMPA > glutamate > kainate > DNQX, which explains published experimental data on GluR2 activation and antagonism strength.

• 出版日期2013