MUC5AC expression correlates with invasiveness and progression of extramammary Paget%26apos;s disease

作者：Hata H; Abe R^*; Hoshina D; Saito N; Homma E; Aoyagi S; Shimizu H

来源：Journal of the European Academy of Dermatology and Venereology, 2014, 28(6): 727-732.

DOI：10.1111/jdv.12156

BackgroundPatients with in situ extramammary Paget%26apos;s disease (EMPD) tend to have a good prognosis, although dermal invasion and metastasis are associated with significantly increased morbidity and mortality. Previous studies have addressed mechanisms underlying the EMPD pathogenesis; however, no molecular markers that reflect invasiveness or progression have been established. %26lt;br%26gt;ObjectiveThis study aims to identify a reliable marker for predicting the risk of invasion and metastasis in EMPD. %26lt;br%26gt;MethodsWe performed an initial microarray screening for in situ, invasive or metastatic lymph node lesions of EMPD. We analysed 44 specimens from 38 primary EMPD cases by immunohistochemical staining. %26lt;br%26gt;ResultsWe found that expressions of MUC5AC directly correlate with invasion and prognosis. Labelling rates of tumour cells were scored by staining intensity on a four-tiered scale (- to 3+) to investigate the correlation between the expression score of these molecular markers and the type of EMPD lesion. All the specimens scored positive (3+) for MUC1 and negative (-) for MUC6. MUC5AC expression was detected in 19 of 44 (43.2%) specimens. Invasive lesions and metastatic lymph nodes tended to express MUC5AC significantly higher than in situ lesions (P%26lt;0.01). MUC2 was positive in 10 specimens (22.7%). There was no significant difference between the degree of MUC2 expression and invasiveness. %26lt;br%26gt;ConclusionThe degree of MUC5AC expression may correlate with the invasiveness and progression of EMPD, and may be a useful marker for identifying high-risk EMPD cases.

• 出版日期2014-6