Attention-Deficit Hyperactivity Disorder and PharmacotherapyPast, Present, and Future: A Review of the Changing Landscape of Drug Therapy

作者：Connolly J J; Glessner J T; Kao C; Elia J; Hakonarson H^*

来源：Therapeutic Innovation & Regulatory Science, 2015, 49(5): 632-642.

DOI：10.1177/2168479015599811

• ADHD
• pharmacotherapy
• pharmacology
• drug
• medication
• adverse events

Attention-deficit hyperactivity disorder (ADHD) is the most common neurobiological disorder in children. Efficacy of pharmacotherapy in treating ADHD symptoms has generally been considerable with at least three-fourths of individuals benefiting from pharmacotherapy, typically in the form of stimulants. In this review, we begin by briefly reviewing the history of pharmacotherapy in relation to ADHD, before focusing (primarily) on the state of the field on themes such as biophysiology, pharmacokinetics, and pharmacogenomics. We conclude with a summary of emerging clinical and research studies, particularly the potential role for precision therapy in matching ADHD patients and drug types.

• 出版日期2015-9