Analysis of Polymer Layers on Red Blood Cell Surfaces with Soft Particle Models

作者：Hyono Atsushi^*; Duval Jerome F L; Ohshima Hiroyuki; Mazda Toshio; Yonezawa Tetsu

来源：Kobunshi Ronbunshu, 2010, 67(12): 654-665.

DOI：10.1295/koron.67.654

• Red Blood Cell
• Electrophoretic Mobility
• Soft Particles
• Enzyme Method

Analysis of human red blood cells surface properties and evaluation of the interactions among red blood cells were done to establish the mechanism of the enzyme method. Electrophoretic mobilities of intact and enzyme-treated red blood cells were analyzed with soft particle theories; one based on the diffuse models could provide further information about the properties of red blood cell surfaces. Therefore, the interaction energies between two red blood cells were evaluated and the closest distances between them were evaluated to decide the agglutinability of cells with a IgG molecule. It was concluded that thinning of the surface layer thickness plays more important role in the enzyme method than reducing the surface layer charge densities.

• 出版日期2010