Direct observation of key intermediates by negative-ion electrospray ionisation mass spectrometry in palladium-catalysed cross-coupling

作者：Vikse Krista L; Henderson Matthew A; Oliver Allen G; McIndoe J Scott^*

来源：Chemical communications, 2010, 46(39): 7412-7414.

DOI：10.1039/c0cc02773a

Negative-ion electrospray ionisation mass spectrometry with an anionic phosphine ligand enables detection of key intermediates in the Sonogashira reaction. MS/MS techniques are used to generate a Hammett plot for the key reductive elimination step.

• 出版日期2010