Acute Kidney Injury after Using Contrast during Cardiac Catheterization in Children with Heart Disease

作者：Hwang Young Ju; Hyun Myung Chul; Choi Bong Seok; Chun So Young; Cho Min Hyun^*

来源：Journal of Korean Medical Science, 2014, 29(8): 1102-1107.

DOI：10.3346/jkms.2014.29.8.1102

• Acute Kidney Injury
• Kidney Injury Molecule-1
• Liver-type Fatty Acid-Binding Protein
• Contrast

Acute kidney injury (AKI) is closely associated with the mortality of hospitalized patients and long-term development of chronic kidney disease, especially in children. The purpose of our study was to assess the evidence of contrast-induced AKI after cardiac catheterization in children with heart disease and evaluate the clinical usefulness of candidate biomarkers in AKI. A total of 26 children undergoing cardiac catheterization due to various heart diseases were selected and urine and blood samples were taken at 0 hr, 6 hr, 24 hr, and 48 hr after cardiac catheterization. Until 48 hr after cardiac catheterization, there was no significant increase in serum creatinine level in all patients. Unlike urine kidney injury molecule-1, IL-18 and neutrophil gelatinase-associated lipocalin, urine liver-type fatty acid-binding protein (L-FABP) level showed biphasic pattern and the significant difference in the levels of urine L-FABP between 24 and 48 hr. We suggest that urine L-FABP can be one of the useful biomarkers to detect subclinical AKI developed by the contrast before cardiac surgery.

• 出版日期2014-8