Association between Q192R paraoxonase 1 polymorphism and serumadipocyte-fatty acid binding protein (FABP4) levels in Mexican women

作者：Ochoa Martinez Angeles C; Ruiz Vera Tania; Orta Garcia Sandra T; Dominguez Cortinas Gabriela; Jimenez Avalos Jorge A; Perez Maldonado Ivan N^*

来源：Annals of Human Biology, 2017, 44(4): 389-391.

DOI：10.1080/03014460.2016.1245785

• Biomarker
• cardiovascular diseases
• FABP4
• PON1 polymorphism
• women

Aim: This study aimed to evaluate the genetic effects of PON1 Q192R polymorphism on serum FABP4 levels in Mexican women.Methods: PON1 Q192R polymorphism was genotyped using a TaqMan allelic discrimination assay and serum FABP4 concentration was measured using an enzyme-linked immunosorbent assay.Results: The distribution of genotype frequencies in the assessed women (PON1 Q192R polymorphism) was QQ=20%, QR=48% and RR=32%. Significantly higher serum FABP4 levels were found in women with genotype QR/RR (20.62.20ng/mL), when compared with the levels found in the QQ group (12.8 +/- 1.70ng/mL) (p=.004). After, the odds ratio (OR) was calculated by binomial logistic regression analysis and a significantly higher OR was found in the QR/RR group when compared with the QQ group (OR=3.45; 95% CI=1.80-16.50; p<.05).Conclusion: The results support an association between 192R-allele of the PON1 polymorphism (Q192R) and increased serum FABP4 levels (suggested as an early biomarker of CVDs risk) in assessed Mexican women.

• 出版日期2017