Down-regulated CUL7 in gastric carcinoma (GC) correlates to GC histopathological features

作者：Pan, Boyu; Ke, Bin; Zhang, Huiqing; Zhao, Gang; Ding, Bowen; Ma, Gang; Liu, Liren^*

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(6): 6357-6363.

• CUL7
• gastric cancer
• histological type
• differentiation degree

As a key component of E3 ubiquitin ligase complex, CUL7 functions as a molecular scaffold to position the F-box protein bound substrate for ubiquitination, thereby participating in a variety of cellular processes. Recently, aberrant expression of CUL7 has been found in many malignancies, but the expression status of CUL7 in human gastric carcinoma (GC) remains unknown. In this study, we determined the CUL7 levels in GC tissues from a large clinical cohort by qRT-PCR, western blot and immunohistochemistry staining. Our results showed that CUL7 level was down-regulated in GC tissues and was associated with the histology and differentiation of GC, implying CUL7 may serve as a potential therapeutic target as well as a histopathological marker for GC patients.

• 出版日期2017
• 单位天津医科大学