A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

作者：Petit Laurent; Botez Iuliana; Tizot Andre; Zard Samir Z^*

来源：Tetrahedron Letters, 2012, 53(26): 3220-3224.

DOI：10.1016/j.tetlet.2012.04.020

• Radical cyclisation
• Radical addition
• Xanthates
• Pyridoazepinones
• Peroxides

Variously substituted novel dihydropyridoazepinones have been prepared by an intermolecular radical addition followed by a radical cyclisation on a pyridine ring. The latter process involved the use of a combination of two different peroxides, an experimental contrivance resulting from a careful product analysis and a better understanding of the cyclisation step.

• 出版日期2012-6-27