Alleviation of Plasma Homocysteine Level by Phytoestrogen α-Zearalanol Might Be Related to the Reduction of Cystathionine β-Synthase Nitration

作者：Zhang, Hui; Sun, Qi; Liu, Teng; Ma, Lu; Zhen, Panpan; Wang, Ke; Lu, Lingqiao; Liu, Xin; Zhang, Xin; Song, Dandan; Zuo, Xiaoyun; Liu, Huirong; Wang, Wen^*

来源：Biomed Research International, 2014, 2014: 143192.

DOI：10.1155/2014/143192

• HORMONE REPLACEMENT THERAPY
• CARDIOVASCULAR EVENTS
• GENE-EXPRESSION
• PEROXYNITRITE
• PROTEIN
• CANCER

Hyperhomocysteinemia is strongly associated with cardiovascular diseases. Previous studies have shown that phytoestrogen alpha-zearalanol can protect cardiovascular system from hyperhomocysteinemia and ameliorate the level of plasma total homocysteine; however, the underlying mechanisms remain to be clarified. The aim of this research is to investigate the possible molecular mechanisms involved in ameliorating the level of plasma homocysteine by alpha-zearalanol. By the successfully established diet-induced hyperhomocysteinemia rat models, we found that, after alpha-zearalanol treatment, the activity of cystathionine beta-synthase, the key enzyme in homocysteine metabolism, was significantly elevated and level of nitrative stress in liver was significantly reduced. In correlation with this, results also showed a decreased nitration level of cystathionine beta-synthase in liver. Together data implied that alleviation of plasma homocysteine level by phytoestrogen alpha-zearalanol might be related to the reduction of cystathionine beta-synthase nitration.

• 出版日期2014
• 单位首都医科大学