Unusual P450 reactions in plant secondary metabolism

作者：Mizutani Masaharu^*; Sato Fumihiko

来源：Archives of Biochemistry and Biophysics, 2011, 507(1): 194-203.

DOI：10.1016/j.abb.2010.09.026

• P450
• Plant secondary metabolism
• Isoquinoline alkaloids
• Oxidative rearrangement
• Methylenedioxy bridge
• Phenol coupling

Plant cytochromes P450 (P450s) participate in a variety of biochemical pathways to produce a vast diversity of plant natural products. The number of P450 genes in plant genomes is estimated to be up to 1% of the total gene annotations of each plant species, implying that plants are huge sources for various P450-dependent reactions. Plant P450s catalyze a wide variety of monooxygenation/hydroxylation reactions in secondary metabolism, and some of them are involved in unusual reactions such as methylenedioxy-bridge formation, phenol coupling reactions, oxidative rearrangement of carbon skeletons, and oxidative C-C bond cleavage. Here, we summarize unusual P450 reactions in various plant secondary metabolisms, and describe their proposed reaction mechanisms.

• 出版日期2011-3-1