Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice

作者：Hosseini Abdolkarim; Mirazi Naser^*

来源：Epilepsy Research, 2014, 108(3): 411-419.

DOI：10.1016/j.eplepsyres.2014.01.008

• Seizure
• Ginger
• Phenobarbital
• Pentylenetetrazole
• Mice

Purpose: Zingiber officinale (Zingiberaceae) or ginger, which is used in traditional medicine has antioxidant activity and neuroprotective effects. The effects of this plant on clonic seizure have not yet been studied. The present study evaluated the anticonyulsant effect of ginger in a model of clonic seizures induced with pentylenetetrazole (PTZ) in male mice.
Materials and methods: The anticonyulsant effect of Z. officinale was investigated using i.v. PTZ-induced seizure models in mice. Different doses of the hydroethanolic extract of Z. officinale (25, 50, and 100 mg/kg) were administered intraperitonal (i.p.), 2 and 24 h before induction of PTZ. Phenobarbital sodium (30 mg/kg), a reference standard, was also tested for comparison. The effect of ginger on to the appearance of three separate seizure endpoints (myoclonic, generalized clonus and forelimb tonic extension phase) was recorded.
Results: The results showed that the ginger extract has anticonyulsant effects in all the experimental treatment groups of seizure tested as it significantly increased the seizure threshold. Hydroethanolic extract of Z. officinale significantly increased the onset time of myoclonic seizure at doses of 25-100 mg/kg (p< 0.001) and significantly prevented generalized clonic (p <0.001) and increased the threshold for the forelimb tonic extension (p <0.01) seizure 2 and 24h before induction of PTZ compared with control group.
Conclusion: Based on the results the hydroethanolic extract of ginger has anticonyulsant effects, possibly through an interaction with inhibitory and excitatory system, antioxidant mechanisms, oxidative stress and calcium channel inhibition.

• 出版日期2014-3