Genetically Modified T Cells for the Treatment of Malignant Disease

作者：Wieczorek Agnieszka; Uharek Lutz^*

来源：Transfusion Medicine and Hemotherapy, 2013, 40(6): 388-402.

DOI：10.1159/000357163

• Adoptive cell transfer
• Chimeric antigen receptor
• CAR
• T-cell receptor
• TCR
• Clinical trial

The broaden application of adoptive T-cell transfer has been constrained by the technical abilities to isolate and expand antigen-specific T cells potent to selectively kill tumor cells. With the recent progress in the design and manufacturing of cellular products, T cells used in the treatment of malignant diseases may be regarded as anticancer biopharmaceuticals. Genetical manipulation of T cells has given T cells desired specificity but also enable to tailor their activation and proliferation potential. Here, we summarize the recent developments in genetic engineering of T-cell-based biopharmaceuticals, covering criteria for their clinical application in regard to safety and efficacy.

• 出版日期2013