Preparation of spherical macroporous poly(lactic-co-glycolic acid) for bone tissue regeneration

作者：Bian, Chunhui^*; Lin, Huiming; Li, Xiaofeng; Ma, Jie; Jiang, Pingping; Qu, Fengyu

来源：IET Nanobiotechnology, 2015, 9(1): 1-4.

DOI：10.1049/iet-nbt.2013.0066

• bioceramics
• bone
• calcium compounds
• drug delivery systems
• emulsions
• materials preparation
• polymer blends
• porous materials
• scanning electron microscopy
• tissue engineering
• spherical macroporous poly(lactic-co-glycolic acid)
• bone tissue regeneration
• emulsion method
• polyvinyl alcohol dispersing agent
• Pluronic F127 porogen agent
• simulated body fluid
• hydroxyapatite
• HAP-PLGA
• drug release
• composite material
• tissue regeneration engineering
• Ca-10(PO4)(6)(OH)(2)

Spherical macroporous poly(lactic-co-glycolic acid) (PLGA) has been synthesised using an emulsion method. Polyvinyl alcohol and Pluronic F127 have been used as dispersing and porogen agent, respectively. The diameter of the spherical PLGA is about 20 m and the pore size of the PLGA macroporous is about 2-2.5 m observed by scanning electron microscopy. After immersing in simulated body fluid, the PLGA materials can induce the formation of hydroxyapatite (HAP) on their surface. The HAP-PLGA has been obtained and used as the host for drug release. Furthermore, the drug-loaded samples possess the various drug release performance by adjusting the thickness of the HAP layer. This highly satisfied composite material is expected to be promising in the applications in tissue regeneration engineering.

• 出版日期2015-2
• 单位哈尔滨师范大学