Hypoxia-Inducible Factor-1 (HIF-1)-Active Cells as a Target for Cancer Therapy

作者：Kizaka Kondoh Shinae^*; Kuchimaru Takahiro; Kadonosono Tetsuya

来源：Journal of Pharmacological Sciences, 2011, 115(4): 440-445.

DOI：10.1254/jphs.10R20FM

• hypoxia-inducible factor (HIF)
• protein transduction domain
• oxygen-dependent degradation
• bioluminescence imaging
• pancreatic cancer

The microenvironment of solid tumors is characterized by low pO(2) that is well below physiological levels. Intratumoral hypoxia is a major factor contributing to cancer progression and is exacerbated as a result of oxygen consumption by rapidly proliferating tumor cells near blood vessels, poor lymphatic drainage resulting in high interstitial pressure, and irregular blood supply through immature tumor vasculature. Hypoxia-inducible factor-1 (HIF-1) is the main transcription factor that regulates cellular responses to hypoxia. Cellular changes induced by HIF-1 are extremely important targets for cancer therapy. Therefore, targeting strategies to counteract HIF-1-active cells are essential for cancer therapy. In this study, we introduce a novel strategy for targeting HIF-1-active cells.

• 出版日期2011-4